Aside from several important mRNA targets of relevance to DM1-specific phenotypes, an interesting auto-regulatory loop that impacts MBNL1/CUG-BP1 ratio was recently proposed based on the observation that MBNL1 and CUG-BP1 bind to each others 3′UTRs to promote mRNA decay of their respective targets (59). Here, CELF1 is linked to myotonic dystrophy type 1.