Taken together with the finding that DDX6 overexpression leads to a more diffuse staining of MBNL1 in the majority of DM1 cells, it was concluded that DDX6, although being a mainly cytoplasmic protein, is able to locally unwind CUG-hairpin structures in the nucleus and potentially displace MBNL1 from the repeats (47). This evidence concerns the gene MBNL1 and myotonic dystrophy type 1.