AICDA and Epstein-Barr virus infection: Whilst classical Hodgkin’s lymphoma appears to be a failed B cell that is prevented from undergoing natural apoptosis by EBV infection, it is likely that the marked chemosensitivity of NHLPL, which characteristically EBV negative [196] stems from the same route as that of DLBCL with ongoing AID activity and the sustained presence of the pro-apoptotic pathways associated with the somatic hypermutation process.