BCL2 and Burkitt lymphoma: These complexes processes of immunoglobulin gene VDJ rearrangement and somatic hypermutation are recognised to be associated with the induction of lymphomagenesis, with VDJ rearrangements particularly linked to malignancy associated translocations including t [8,14], t[14:18] and BCL2 [144-147], whilst somatic hypermutation is linked to the myc translocations seen in Burkitt’s lymphoma [148].