Due to our obtained results that indicated the increased frequencies of CD8+ T cells in the tumor tissues and high CD4+/CD8+ ratio in the dLN, we decided to study the expression of CXCL10, as an important chemotactic factor for T cells and also granzyme B, as an effector molecule for CD8+ T cells function, in the tumoral and normal breast tissues and dLN of the patients. The gene discussed is CD4; the disease is neoplasm.