HLA-B*53 (6.43% vs. 2.93%; p = 0.050, OR = 2.28, 95% CI = 1.05–4.94, pc =1.60) and HLA-C*16 (10.4% vs. 5.44%; p = 0.030, OR = 2.02, 95% CI = 1.10–3.67, pc = 0.48) were also more frequent in B leprosy patients than in healthy controls. Here, HLA-C is linked to leprosy.