Notably, we also showed that ERp57 depletion decreased IL-6, a major upstream activator of STAT3 [8, 26], in radioresistant laryngeal cancer cells, suggesting that ERp57 regulates STAT3 activity by modulating not only STAT3 activity directly but also IL-6 expression, thereby creating a positive feedback loop. This evidence concerns the gene PDIA3 and laryngeal carcinoma.