Similar to the effect of STAT3 inhibition, Mcl-1 depletion also elevated radiation-induced cell death (Fig. 4D and E) and reduced the survival of RR-HEp-2 cells in response to various doses of radiation (Fig. 4F), but it did not affect ERp57 expression and STAT3 phosphorylation (Fig. 4D), indicating that STAT3-Mcl-1 regulation is essential for the radioresistance of laryngeal cancer cells. Here, PDIA3 is linked to laryngeal carcinoma.