HDAC inhibitors have been shown to induce apoptotic cell death and growth arrest in various cancer cells, promote reactive oxygen species generation, and inhibit angiogenesis through downregulation of genes involved in regulating angiogenesis, including hypoxia-inducible factor 1 alpha (HIF1α) and vascular endothelial growth factor (VEGF) [8]. This evidence concerns the gene VEGFA and cancer.