The oncogenic potential of eIF4E is sternly dependent on phosphorylation at serine 209 residue by MNK1/2 which increase the affinity of eIF4E for 5′ cap of mRNA.4 Both MNK and p-eIF4E are found to be up-regulated in various cancers [19,32-34]. Here, MKNK1 is linked to cancer.