ATP7A and posterior cortical atrophy: In the present study, the functional consequence of AR and MNK knockdown on LNCaP cell proliferation provides proof-of-principle for the importance of AR and MNK mediated signaling in upholding growth and survival of PCa cells, and also authenticates that AR and MNK are the prime target of NR (VNLG-152) for mediating growth inhibitory effects in PCa cells.