AR and posterior cortical atrophy: Our findings indicate that synchronized dual inhibition of AR signaling and MNK mediated eIF4E activation by NRs in PCa cells results in blockade of cell cycle progression and induction of caspase dependent apoptosis which is in line with the earlier reports that demonstrate that targeting AR or MNK in PCa cells results in induction of cell cycle arrest and apoptosis (19,37,38).