AR and posterior cortical atrophy: Our data reveal that NRs are capable of inhibiting the growth and progression of PCa by directly targeting both AR signaling and eIF4E translational machinery via enhancing AR and MNK degradation through the ubiquitin-proteasome pathway, which in turn led to inhibition of downstream events that promote cell growth, proliferation, colony formation, apoptosis evasion, invasion and metastasis.