Interestingly, studies have identified that inhibition of miR-125b enhanced the chemosensitivity of glioblastoma stem cells to temozolomide through regulating Bak1 (Bcl-2 antagonist killer 1) and PIAS3 (protein inhibitor of activated signal transducer and activator of transcription) [42-44]. The gene discussed is PIAS3; the disease is glioblastoma.