The interaction between hyaluronan and CD44 activates the stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells [43], and it can also lead to Bcl-2 expression and chemoresistance in breast cancer cells [44]. The gene discussed is STAT3; the disease is ovarian neoplasm.