Along with the increased expression of pSrc (Tyr 416) in the intestinal tumor tissues of the ApcMin/+;Slit2 mice and DMH/DSS-Slit2 mice, activation of Slit2/Robo1 signaling was also found to be associated with a marked decrease in the expression of E-cadherin in the tumor tissues (Figure 5C and Supplementary Figure 6D). This evidence concerns the gene CDH1 and intestinal neoplasm.