SLIT2 and neoplasm: Upon macroscopic examination, it was revealed that ApcMin/+;Slit2 mice and the DMH/DSS-Slit2 mice exhibited a significantly increased tumor incidence (the number of tumors) and tumor burden (average tumor size), compared with ApcMin/+ mice and DMH/DSS-C57 mice (Figure 3, A-C, and Supplementary Figure 4, A-C).