We next investigated the impact of Slit2/Robo1 signaling on the initiation and development of intestinal tumors using the Slit2 transgenic (Slit2-Tg) mice model in which Slit2 is genetically overexpressed (Supplementary Table 1 and Supplementary Figure 2, A-C). This evidence concerns the gene ROBO1 and intestinal neoplasm.