CXXC5 and acute myeloid leukemia: Increased levels of the potential tumor suppressor gene TSC22D1. This gene (TSC22 domain family, member 1) shows increased levels after CXXC5 knockdown and encodes a transcriptional regulator [56] that is a potential tumor suppressor in human AML [57]; it can also contribute to induction of apoptosis in human gastric and breast cancer cells and increase cancer cell sensitivity to anticancer drugs [56] and radiation [58].