Those genes showing high expression in CXXC5HIGH primary human AML cells and being significantly altered (i.e. increased) after CXXC5 knockdown included one potential tumor suppressor (TSC22), the cytokine Angiopoietin 1, a selenium transport protein and the hematopoietic growth factor receptor KIT. The gene discussed is TSC22D1; the disease is acute myeloid leukemia.