Those genes showing high expression in CXXC5HIGH primary human AML cells and being significantly altered (i.e. increased) after CXXC5 knockdown included one potential tumor suppressor (TSC22), the cytokine Angiopoietin 1, a selenium transport protein and the hematopoietic growth factor receptor KIT. This evidence concerns the gene CXXC5 and acute myeloid leukemia.