MMP9 and acute myeloid leukemia: Thus, the major differences between CXXC5HIGH and CXXC5LOW AML include the following functional networks (Table 2): (i) HLA-class I-CLEC-LILR; (i) the chemokine-chemokine receptor system (including MMP9); (iii) the interleukin system; (iv) the complement system; and (v) the lysosomal function and thereby possibly also regulation of autophagy and cell viability [21, 22].