Our bioinformatical analyses demonstrated that CXXC5 expression showed a strong association both to (i) the overall expression profiles of the transcription factor heptade associated with adverse prognosis (Figure 3); and (ii) the overall signature of 35 stem cell-associated genes used to identify AML patients with high-risk disease (Figure 4). Here, CXXC5 is linked to acute myeloid leukemia.