Thus, clustering analysis shows that CXXC5/RINF expression shows a strong correlation with several other transcription factors involved in hematopoiesis, including several members of the transcription factor heptade (GATA2, RUNX, ERG, the LM02 recruitment factor LYL1) that is associated with adverse prognosis in AML [35]. The gene discussed is CXXC5; the disease is acute myeloid leukemia.