Increased levels of the potential tumor suppressor gene TSC22D1. This gene (TSC22 domain family, member 1) shows increased levels after CXXC5 knockdown and encodes a transcriptional regulator [56] that is a potential tumor suppressor in human AML [57]; it can also contribute to induction of apoptosis in human gastric and breast cancer cells and increase cancer cell sensitivity to anticancer drugs [56] and radiation [58]. The gene discussed is TSC22D1; the disease is acute myeloid leukemia.