Benekli et al. [69] described an association between high constitutive STAT3 activation (i.e. high Y705 phosphorylation) and adverse prognosis, whereas a recent study described improved survival for patients showing high STAT3 Y705 and S727 phosphorylation in their AML cells in response to cytokine stimulation [74]. This evidence concerns the gene STAT3 and acute myeloid leukemia.