We find that selective HDAC1,2 inhibition alone is sufficient to increase BMF gene transcription in the refractory EZH2GOF DLBCL cells, and therefore, pan-HDI induction of BMF gene expression is likely to be mediated in large part due to their inhibition of HDAC1,2 activity. This evidence concerns the gene HDAC1 and diffuse large B-cell lymphoma.