Inhibiting EZH2 activity or HDAC1,2 activity therefore shifts the balance towards the ‘H3K27ac>H3K27me3’ state, which might lead to the activation of select DNA damage response genes and trigger either cell cycle arrest or death in the EZH2GOF mutant DLBCL cells. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.