These mutations occur in tyrosine 641 (Y641) residue within the catalytic SET domain of EZH2, and are found in two types of lymphomas: 21.7% of germinal center-type diffuse large B-cell lymphoma (GC-DLBCL) and 7.2% of follicular lymphoma (FL) [6]. This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.