EZH2GOF DLBCL cells appear to be more sensitive to selective inhibition of HDAC1,2 activity than inhibition of EZH2 activity, because we observed death and/or cell cycle arrest in SUDHL4 and Karpas-422 cells as early as 48h or 72h following treatment with ACY-957 (Supplementary Figure 2 and Figure 3). This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.