Knockdown of BBAP delayed the accumulation of 53BP1 (a key repair protein) at DNA breaks induced by doxorubicin, suggesting that BBAP, via H4K91ub1, might protect DLBCL cells from DNA damage by facilitating 53BP1-mediated repair of double-strand DNA breaks [17]. This evidence concerns the gene DTX3L and diffuse large B-cell lymphoma.