In addition, various immunohistochemical studies have now shown that the localization of the brachyury protein varies among tumor types, being exclusively nuclear or cytosolic in chordomas or hemangioblastomas, respectively [8, 10, 11], while detected in the nucleus and/or the cytosol of human carcinoma cells [13, 16, 17]. Here, TBX1 is linked to carcinoma.