MTHFR and hyperhomocysteinemia: In a logistic-regression analysis in which adjustments were made for age and gender (Table 5) and in which hyperhomocysteinemia, presence of factor-V-Leiden- polymorphism, the prothrombin-gene-mutation, lupus anticoagulant and MTHFR-gene-mutation were included in the same model, only the presence of factor-V-Leiden-gene-mutation, hyperhomocysteinemia and MTHFR-gene-mutation could be identified as independent risk factors (Table 5).