To evaluate whether FAS-FASL signaling participates in MP clearance, we first compared subretinal MP numbers in light-challenged WT (Fig5E), FASL-defective (FasLgld/gld mice, Fig5F), and FAS-defective (Faslpr/lpr mice, Fig5G) mice (FasLgld/gld and Faslpr/lpr mice develop lymphadenopathy and systemic autoimmune disease with age, making it difficult to evaluate age-dependent MP accumulation at 12 months). This evidence concerns the gene FASLG and Lymphadenopathy.