Cx3cr1 deficiency in mice leads to a strong increase of subretinal MP accumulation with age, after light challenge or laser injury (Combadiere et al, 2007; Raoul et al, 2008; Ma et al, 2009), in diabetes (Kezic et al, 2013) and in a paraquat-induced retinopathy model (Chen et al, 2013). The gene discussed is CX3CR1; the disease is diabetes mellitus.