ABCA4 and age-related macular degeneration: Recent evidence strongly suggests that CCL2/CCR2-dependent subretinal MP accumulation is an important contributing factor in photoreceptor degeneration in models of photo-oxidative stress (Rutar et al, 2012; Suzuki et al, 2012), in the Abca4−/−Rdh8−/− mouse Stargardt/AMD model (Kohno et al, 2013), in the carboxyethylpyrrole immunization-induced AMD model (Cruz-Guilloty et al, 2013), and in the age- and light-induced photoreceptor degeneration of Cx3cr1−/− mice (Combadiere et al, 2007; Sennlaub et al, 2013).