NFKB1 and idiopathic pulmonary arterial hypertension: Inhibition of NFκB activity attenuated TRPC6 expression and decreased agonist activated Ca2+ influx in PASMCs of IPAH patients harboring the c.1-254G allele [32].Others SNPs in this region could facilitate interactions of several transcription factors (nuclear factor of activated T-cells (NFAT) and Activation Protein-1 (AP-1)) increasing TRPC6 transcription.