TRPV4 and idiopathic pulmonary arterial hypertension: It has been shown that upregulated expression of TRPM7 (transient receptor potential cation channel, subfamily M, member 7), TRPV4 (transient receptor potential cation channel, subfamily V, member 4) and TRPC6 channels in PASMC from IPAH patients seems to be, at least in part, the cause for the enhanced increase in [Ca2+]cyt induced by mechanical stimuli (e.g., flow shear stress and stretch).