The GSTM1-null genotype, the AKR1C3 (Ex1-70C > G), OGG1 (Ex6-315C > G) genotypes were closely associated with increased risk of lung cancer in Xuanwei County, and their odds ratios (95%CI) were 2.3 (1.3-4.2), 1.8 (1.0-3.5) and 1.9 (1.1-3.3), respectively. Here, GSTM1 is linked to lung cancer.