In addition, ilimaquinone has been shown to activate hypoxia-inducible factor-1 (HIF-1) [13] and induce cell cycle arrest at the G1 phase through upregulation of the growth arrest and DNA damage-inducible gene 153 (CHOP/GADD153) in prostate cancer cells [14]. The gene discussed is DDIT3; the disease is prostate carcinoma.