Alternatively, the hepatic inflammation in Traf6∆TEC mice may be due to the reduced susceptibility of effector T-cells to Treg-mediated suppression, as CD4+ T-cells isolated from AIH patients were shown to exhibit reduced expression of the inhibitory receptor, Tim-3, which binds to galectin-9 on Tregs and induces effector T-cell death [10,103]. Here, CD4 is linked to autoimmune hepatitis.