BRD4 and colonic neoplasm: If so, further structure analysis of BRD4 isoforms would be necessary for revealing the association between BRD4 expression level and its role in colon cancer tumorigenesis and metastasis, although we have found that BRD4, most likely the short isoform, has an increasing expression in both colon cancer cell lines and colon cancer tissues, indicating a pro-oncogenic role in CRC.