First, different isoforms of BRD4 may exist in different cancers and the account of each isoform may vary in different cell lines, which is consistent with our study that both short isoform and long isoform express in colon cancer cells; Second, we couldn’t make a conclusion that the two isoforms have opposing functions, but it is possible that they might somehow be controlled and regulated by each other. Here, BRD4 is linked to malignant colon neoplasm.