The paucity of information in this regard prompted us to undertake an immunohistochemical analysis of H1x, H3K9me3, H4K20me3, SETDB1 and SUV39H1 in a large series of astrocytic tumors in order to investigate the interrelations between the expression levels of these molecules and their potential importance in glioma progression. Here, SETDB1 is linked to central nervous system cancer.