Rapamycin alleviated disease progression in ALS TDP‐43 mice (Wang et al. 2012), but augmented motor neuron degeneration in ALS mouse models with SOD1 mutations (Zhang et al. 2011), with an adverse effect on muscle performance (Bhattacharya et al. 2012). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.