IFNG and bacterial infectious disease with sepsis: The homologous triple-prime-boost plasmid DNA vaccine pKarp47(×3) achieved the highest number of O. tsutsugamushi–specific, sustained IFN-γ–producing PBMCs, which was associated with sterile immunity, the lowest frequency of eschar formation, the shortest duration of bacteremia, the longest duration until onset of bacteremia, the lowest bacterial biomass, as well as reduction of liver transaminases (Table III).