In addition, the mean number of elastin stains per case increased from 0.10 (SE, 0.41) to 2.51 (2.06) (p < 0.001), while the mean number of tumor-containing blocks per case remained constant [8.28 (6.69) vs. 8.12 (4.07); p = 0.761]. This evidence concerns the gene ELN and neoplasm.