Factors independently associated with estimated VI detection rates of ≥10% included (1) practice in a university-affiliated center, (2) a sub-specialist interest in GI pathology, and (3) application of the “orphan artery criterion” (i.e., tumor nodule adjacent to an artery where residual smooth muscle or elastin can be demonstrated on H&E or special stains) (18). The gene discussed is ELN; the disease is neoplasm.