Dendritic cells have long been known to present MHCI-bound antigens to CD8+ T cells through two main pathways: direct presentation of endogenous viral antigens when DCs are virally infected (Figure 1A), and cross-presentation of exogenous antigens from dying tumor cells and virally infected cells that are phagocytosed and processed (57, 58) (Figure 1B). Here, CD8A is linked to neoplasm.