HBEGF and neoplasm: Further, by analyzing OT-I proliferation in CD11c-diphtheria toxin receptor (DTA) mice [in which CD11c+ DCs are removable by diphtheria toxin (DT) treatment] inoculated with OVA/H-2Kb tumor cells, the authors demonstrated that DCs are essential for OT-I proliferation in response to the tumor cell-derived OVA peptide–H-2Kb complexes in vivo (35).