Specifically, it was shown that when H-2q mouse bone marrow-derived DCs (BMDCs) were co-cultured with dying H-2b tumor cell lines expressing ovalbumin (OVA), the H-2q BMDMs acquired the OVA peptide–H-2Kb complexes from the tumor cells, and subsequently activated OT-I CD8+ T cells expressing the TCR that recognizes the OVA peptide on H-2Kb (Figure 1C). This evidence concerns the gene CD8A and neoplasm.