BTN3A1 and neoplasm: Our study shows a mandatory role for the BTN3A1 isoform in the specific detection of human distressed cells (e.g., tumor and mycobacteria infected cells) by human Vγ9Vδ2 T cells, which strongly suggested that BTN3A1 molecule represent a major species-specific determinant regulating the antigenic reactivity of human Vγ9Vδ2 T cells (60).