According to our data (Periodic Report 2 - SICA-HF 1), incubation of isolated platelets with TNF-α in concentrations of 0.05 and 1 ng/mL in the reaction media decreases collagen-induced cell aggregation in group of patients with metabolic abnormalities and in healthy volunteers, though this response is significantly more pronounced in MetS patients. Here, TNF is linked to metabolic syndrome.