INS and obesity due to melanocortin 4 receptor deficiency: M. Trovati et al. demonstrated similar effects of various insulin concentrations on platelet aggregation and cGMP contents in different subjects, namely: supraphysiological concentrations (1920 pmol/L) in obese or diabetic patients with obesity and more physiological concentrations (240–480 pmol/L) in healthy individuals (Trovati et al., 1995).