According to our data on healthy volunteers and patients with MetS and heart failure (Ogurkova et al., 2012), platelets, incubated with the physiological concentrations of insulin (1 nM) for 3 min, respond with decrease in a degree and rate of collagen-induced platelet aggregation, determined based on the curves of the mean aggregate size and light transmission. The gene discussed is INS; the disease is metabolic syndrome.