On the other hand, more recently, it has been described a beneficial effect of exposure to environmental enrichment in anxiety-related behaviors (measured in the EPM test) that was correlated with changes in brain-derived neurotrophic factor (BDNF) expression in the central amygdala, hippocampus and the caudate putamen (Ravenelle et al., 2014). The gene discussed is BDNF; the disease is Anxiety.