YAP1 and infectious otitis media: To address this question, we concomitantly ablated YAP1 in N1/2 cDKO mice and subjected them to AOM-mediated colon carcinogenesis as outlined in Figure 2B. Significantly, removal of one YAP1 allele was sufficient to reduce tumor formation in N1/2 cDKO mice from 15 to 5 nodules on average (compare Figures 2D and 4F).