Vertebrate CD36 is involved in lipid scavenging (Stuart et al., 2005), and activates JNK (Baranova et al., 2008, Rahaman et al., 2006), while mice with JNK-deficient macrophages present with decreased production of cytokines, including IL-6, and are protected against insulin resistance (Han et al., 2013). This evidence concerns the gene MAPK8 and Insulin resistance.