Silencing of myeloid differentiation primary response gene 88 (Myd88), immune deficiency (Imd), and TGF-β-activated kinase 1 (Tak1) in macrophages (Figure 7D) did not rescue Drosophila lifespan on lipid-rich diet. Here, MYD88 is linked to hyperinsulinemic hypoglycemia, familial, 4.