Ly6Chigh MO conversion to Ly6Clo anti-inflammatory macrophages with a restorative phenotype in murine hepatic fibrosis requires the upregulation of genes encoding molecules of the anti-inflammatory macrophage program, like CX3CR1, or with anti-fibrotic effects, like CD74 [38]. The gene discussed is CX3CR1; the disease is Hepatic fibrosis.