In addition, melanoma subtypes with non-mutated or non-amplified BRAF, NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog, Gene ID: 4893), KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Gene ID: 3815), or MAP2Ks (mitogen-activated protein kinase kinase, Gene IDs: 5604-5609) lack molecular targets and present a need to deepen our knowledge of the molecular signature of melanoma. This evidence concerns the gene NRAS and melanoma.