At chromosome 1 band 22q13.2, chr22:41468899-41849552, EP300 (E1A binding protein p300, Gene ID: 2033), MKL1 (megakaryoblastic leukemia 1, Gene ID: 57591), ACO2 (aconitase 2, Gene ID: 50), and RANGAP1 (Ran GTPase activating protein 1, Gene ID: 5905) are among the significantly amplified genes in melanoma with a q-value of 1.0892e-06. This evidence concerns the gene ACO2 and melanoma.