Tripterine modulates the expression of proteins with angiogenic and metastatic activities (MMP-9, intercellular adhesion molecule (ICAM)-1, VEGF) and those involved in cell survival (inhibitor of apoptosis protein (IAP)-1, X-linked (X)-IAP, B-cell lymphoma (Bcl)-2, Bcl-xL, flice inhibitory protein (cFLIP), survivin) or cell proliferation (cyclin D1, COX-2) in tumor cells [183], [184]. This evidence concerns the gene VEGFA and neoplasm.