As expected, the treatment-naïve active acromegaly patients had significantly higher IGF1, marginally elevated but insignificant LDL, triglyceride (TG), hsCRP, BMC, BMD, TBF, LBM, and LV-mass as compared with acromegaly patients with GHD at baseline and even after treatment. The gene discussed is IGF1; the disease is acromegaly.