MHV68 latency also protected IL-6, Caspase-1 and Caspase-1;Caspase-11 deficient mice from Listeria-induced lethality, indicating that the ability of latent infection to complement a genetic immunodeficiency is not restricted to mutation of Hoil-1. The gene discussed is RBCK1; the disease is disease arising from reactivation of latent virus.