HOIL-1 KO mice (Tokunaga et al., 2009) were born at Mendelian ratios and, in contrast to SHARPIN-deficient mice, failed to develop TNFα-driven inflammatory skin disease (Ikeda et al., 2011; Gerlach et al., 2011; Tokunaga et al., 2011; Tokunaga and Iwai, 2012) and exhibited normal histology of lymphoid organs, liver, lung, and kidney, and the presence of Peyer's patches along the small intestine (not shown). The gene discussed is SHARPIN; the disease is inflammatory skin disease.