TNF and inflammatory skin disease: HOIL-1 KO mice (Tokunaga et al., 2009) were born at Mendelian ratios and, in contrast to SHARPIN-deficient mice, failed to develop TNFα-driven inflammatory skin disease (Ikeda et al., 2011; Gerlach et al., 2011; Tokunaga et al., 2011; Tokunaga and Iwai, 2012) and exhibited normal histology of lymphoid organs, liver, lung, and kidney, and the presence of Peyer's patches along the small intestine (not shown).