We show that macrophages do not produce detectable levels of CCL2, yet ex vivo isolated adipocytes from obese adipose tissue (Figure 3B) produce higher amounts than in vitro differentiated 3T3-L1 cells (Figure 3A), although the levels of adipocyte CCL2 production are in general very low when compared to the levels produced by tumor cells. Here, CCL2 is linked to neoplasm.