In an effort to evaluate the effects of expression of a truncated CD22 protein on the clonogenicity and self-renewal rate of leukemia and lymphoma cell lines, we cloned wildtype full-length (FL) human CD22 cDNA and a truncated human CD22 cDNA that lacks exons 12–14 (CD22ΔE12–14) into the pCL6-2AEGwo lentiviral vector containing a 2A-like peptide (Figs. S4, 5A1, A2 & B1). Here, CD22 is linked to leukemia.