ITIH4 and HIV infectious disease: Recently, peptide microarray studies of plasma from RV144 vaccine recipients identified the crown of the V3 loop (304RTSINI..GPGQVFYRT320) as a highly immunogenic region and showed that when vaccine recipients had low gp120-specific plasma IgA, high responses to this linear peptide were associated with a decreased risk of HIV infection (OR = 0.49, p = 0.007) (Gottardo et al., 2013).