ADAM17 and rheumatoid arthritis: These conflict data in cytokine modulation in serum may be due to differences in the short observational periods (12 wks) and small sample numbers (n=7) in the report by Marti, et al. Collectively, ADAM17 would be an important to modulate cytokine expression and to cleavage from cells, and also seems to be sensitive for effectiveness of ABT therapy in patients with RA.