In the present study, we showed that serum concentration of ADAM17 was increased in patients with RA in compared to normal individuals, and a significant correlation between ADAM17 and CX3CL1, which is involved in the pathogenesis of rheumatoid synovitis and also related vasculitis (25-27) , was seen in RA patients at baseline. This evidence concerns the gene CX3CL1 and rheumatoid arthritis.