86 demonstrated that activating Nodal contributed to VM formation by increasing VE-cadherin expression. Inhibiting Nodal expression prevented VM formation and melanoma cell invasiveness by decreasing keratin and VE-cadherin. Additionally, cAMP, through VE-cadherin redistribution, was able to enhance endothelial barrier properties and promote cell adhesion. VM formation could be inhibited by activating the Nodal signal mediated by cAMP 84. This evidence concerns the gene CDH5 and melanoma.