Generally, VM characteristics can be summarized as follows: (i) positive PAS and negative CD31 straining; (ii) the channel is lined by tumour cells rather than endothelial cells; (iii) the expression of a multipotent, stem cell-like phenotype; (iv) ECM remodelling and (v) VM has connection with the tumour microcirculation system, providing blood for tumour growth. The gene discussed is PECAM1; the disease is neoplasm.