In agreement with our previously published studies on the full cohort, anti-CII serum levels and PBMC-derived ΤΝFα associated with baseline CRP and ESR, whereas anti-cyclic citrullinated peptide version 2 (CCP2) and RF associated with an increased rate of cartilage destruction after 2 years, again arguing that the anti-CII-associated acute-onset RA phenotype differs from the bad long-term prognosis associated with the traditional serological markers RF and anti-CCP2 [1,35,36]. This evidence concerns the gene AGBL2 and rheumatoid arthritis.