The specific regulation of PD-L1 expression by miR-197 was validated by qRT-PCR analysis, demonstrating both a significant inhibitory effect of pre-miR-197 in A549 and PC14CDDP cells and a stimulating effect of LNA-miR-197 on PD-L1 expression in three lung cancer cell lines (Figure 5a). The gene discussed is CD274; the disease is lung carcinoma.