The eight variables included in the final DETECT algorithm were derived from univariable and multivariable statistical analyses; some of these variables have previously been verified as predictive factors for the presence of SSc-PAH, such as FVC/DLCO [8-10], NT-proBNP [11,12], telangiectasia [20], ACA [21,22], serum urate [23,24], and TRV [2]. Here, NPPB is linked to systemic sclerosis.