In this study, we show that there is a positive correlation between expression of Pak1 and meningioma tumor grade, and that inhibiting group I Paks, either by knockdown or by small molecule inhibitors, impairs proliferative and survival signaling, and slows the growth of benign and malignant NF2-null meningioma cells, both in vitro and in vivo. This evidence concerns the gene NF2 and meningioma.