As Frax1036 has few off-targets (Supplementary Fig. S3), these data, in combination with the shRNA data shown in Fig. 1, suggest that blockade of group I Pak function alone is sufficient to suppress the growth of NF2-deficient benign or malignant meningioma [9, 32]. Here, NF2 is linked to Anaplastic (Malignant) Meningioma.