Notably, whereas both NF2−/− meningioma cell lines (Ben-Men and KT21) were highly sensitive to PF3758309, with IC50 values in the low to mid nM range, NF2-expressing meningioma cells showed much less sensitivity to this compound (IC50 3.4 μM and 5.3 μM for MN328 and MN525 cells, respectively). Here, NF2 is linked to meningioma.