Immunohistochemical staining study indicated that p53 and p21Cip1/Waf1 expressions were increased in the tumor tissues derived from the miR-526b-expressing cells compared with those in the tumors from the NC-transfected A549 cells (P < 0.01; Fig. 6E), while expression of Ku80 and Ki67 was decreased (P < 0.01; Fig. 6E). This evidence concerns the gene MKI67 and neoplasm.