MAPK8 and central nervous system cancer: To elucidate the signaling mechanisms involved in MMP2 upregulation following WNK2 abrogation, we next examined the effect of WNK2 expression in the activation of ERK, JNK, p38, and SRC, pivotal molecules in signaling pathways involved in different MMPs positive regulation, as well as in gliomas' signaling mechanisms [22–29].