The results showed that that enhanced expression of STAT3 in GC cells (SGC-7901) promoted the proliferation, migration and invasion of HUVECs (Figs. 4A–D; e, LV-NC vsf, LV-STAT3), whereas knockdown of endogenous STAT3 (AGS) inhibited these behaviors in HUVECs (Figs. 4E–4H; e, STAT3-shcontrol vs STAT3-shRNA). The gene discussed is STAT3; the disease is gastric cancer.