Expression and constitutive activation of AKT, a downstream target of the PI3K has been delineated in primary medulloblastoma tumour samples [5–7], In accordance with these findings, we show that the four investigated medulloblastoma cell lines were phosphorylated at the catalytic sites T308 and S473 of AKT (Figure 3). The gene discussed is AKT1; the disease is neoplasm.