A crosstalk between the PI3K/AKT pathway and STAT3 signaling network has recently been suggested [33] and indeed MEB-Med-8A exhibit a reduction of STAT3 phosphorylation and STAT3 protein levels upon GDC-0941 treatment, while in the other medulloblastoma cell lines this interaction was not observed. This evidence concerns the gene AKT1 and medulloblastoma.