FGFR1 and posterior cortical atrophy: Moreover, reducing ectopic or endogenous expression of CR-1 in 22Rv1/CR-1 and VCaP cells resulted in a down-regulation of FGFR1 expression and/or activity in these cells consistent with the notion that CR-1 can positively regulate FGFR1 signaling in PCa cells (Figure 4D).