By contrast, targeting FGFR3 had little to no effect on TWIST1, SNAI1, E-cadherin or vimentin expression in the 22Rv1/CR-1 cells suggesting that FGFR1 has an important role in enforcing the mesenchymal phenotype in CR-1 overexpressing PCa cells (Figure 4H–4I). The gene discussed is SNAI1; the disease is posterior cortical atrophy.