AKT1 and posterior cortical atrophy: Another aspect emerging from this study is that perturbation of oncogenic signaling pathways (PI3K/AKT, FGFR/MAPK) which are activated downstream of CR-1 can impair the EMT program and the expression of EMT-TFs such as TWIST1, ZEB1 and ZEB2. Inhibition of the expression of these EMT-TFs, can disrupt EMT in PCa cells.