Another intriguing aspect emerging from our study is the possibility that some mesenchymal-like cancer cells may be using PI3K/AKT-signaling to regulate FGFR signaling, an effect evocative of recent studies which established the role of PI3K/AKT in upregulating the expression and/or activity of certain RTKs such as ERBB3 [46, 47]. Here, AKT1 is linked to cancer.