Our results showed that JARID1B and FBL proteins are co-localized in a majority of epithelial cells in prostate tumors of Ptenpc−/−; Trp53pc−/−; Skp2−/− mice, but not in that of Ptenpc−/−; Trp53pc−/− mice (Figure 5E and Supplementary Figure S6B). This evidence concerns the gene KDM5B and prostate neoplasm.