In addition, IHC results also showed that TRAF6 levels were strikingly increased in prostate tumors of Ptenpc−/−; Trp53pc−/−; Skp2−/− mice, as compared to that of Ptenpc−/−; Trp53pc−/− mice (Supplementary Figure S5C). Here, TRAF6 is linked to prostate neoplasm.