PTEN and posterior cortical atrophy: Importantly, we discovered that Skp2 elevation was highly correlated with the increased levels of H3K4me3 in primary (Data not shown) and recurrent PCa tissues in mice upon oncogenic stimulation (Pten/Trp53 loss) (Figure 2E), whereas Skp2 ablation dramatically reduced H3K4me3 (Figure 1F and 2A).